A recent study indicates that individuals who stop using blockbuster GLP-1 drugs like Mounjaro or Wegovy can put back on reduced body mass far faster than those who stop conventional lifestyle programs.
Research printed in a major medical journal demonstrates that while overweight people frequently drop about a fifth of their body weight while using the jabs, the mass returns at an average rate of 0.8 kg per month once they quit.
"People using such treatments need to be informed of the potential of quick weight regain when the medication is stopped," warns researcher Dr. Susan Jebb.
This pace of regain means a return to original mass within about a year and a half.
Weighing Therapies
The study, which examined dozens of studies involving thousands of patients, compared the results of the injectable medications with other pills.
Researchers note that people who lose weight through dieting generally have a more gradual creep back—approximately 100 grams monthly—post-intervention.
The Reason for the Fast Rebound
Experts propose the way of the injections accounts for the amplified rebound.
These medications copy a natural hormone called GLP-1, which helps regulate hunger.
"Artificially providing GLP-1 levels far above than the body's typical production might result in the body to produce less of its own natural hormone, and could reduce responsiveness to its actions," explained Dr. Adam Collins, a dietetics specialist.
"Discontinuation of this medication leads to hunger is uncontrolled, making excessive eating much more probable."
A Lifelong Condition?
The NHS advise the jabs for people with weight-linked medical conditions, alongside prescribed lifestyle changes.
Many experts contend that, considering the likelihood of weight regain, the treatment should be considered ongoing.
This perspective is reinforced by pharmaceutical companies, who note that the findings "emphasize the long-term nature of obesity," akin to managing diseases like high blood pressure.
User Accounts
People who have discontinued the medication describe a sudden return of hunger.
"It felt as if something that goes on and you become extremely hungry," said an individual.
This challenge is exacerbated if patients have not established sustainable lifestyle or habit modifications during therapy.
Growing Interest
Figures indicate that a significant number of people in the UK have tried these injections in the past year, with desire remaining high.
- Use is greater among women than males.
- The middle-aged demographic shows the highest level of interest.
- Many obtain the drugs through private prescriptions rather than public health services.
Finally, experts emphasize that while the jabs are potent tools for shedding pounds, they are not a permanent cure and maintained weight loss likely depends on combined behavioural management.
